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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Carnosic acid, Cisplatin
Phytochemical Name Carnosic acid (PubChem CID: 65126 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 228
Pair Name Carnosic acid, Cisplatin
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Gene Regulation Down-regulation Expression ARG1 hsa383
Up-regulation Expression CD8A hsa925
Up-regulation Expression FASLG hsa356
Up-regulation Expression GZMB hsa3002
Up-regulation Expression IFNG hsa3458
Down-regulation Expression MMP9 hsa4318
Up-regulation Expression PRF1 hsa5551
In Vitro Model A9 [Mouse Lewis lung carcinoma] Malignant tumors of the mouse pulmonary system Mus musculus (Mouse) CVCL_S007
In Vivo Model Mouse LLC (Lewis lung cancer) cells (5×10⁶ cells in 0.1 mL) were injected into the right flank of C57BL/6 mice.
Result Our study proved that the functional suppression of MDSC by carnosic acid promoted the lethality of CD8 T cells, which contributed to the enhancement of anti-lung cancer effect of cisplatin.
03. Reference
No. Title Href
1 Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. Chin J Nat Med. 2018 Dec;16(12):907-915. doi: 10.1016/S1875-5364(18)30132-8. Click
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